HiSiaddi is an innovative foreign trade service provider driven by dual engines of technology transformation and foreign trade services. It has established a "1+2+3+4=1" service system and can supply raw β-nicotinamide mononucleotide (β-NMN) sourced from multiple well-known original manufacturers. As a tech-driven foreign trade enterprise, HiSiaddi has repeatedly proposed formulation optimization schemes and application improvement suggestions for β-NMN products through technological transformation cooperation with factories and precise market insight. Below is a consultation case of HiSiaddi on β-NMN product formulation optimization.
Contact HiSiaddi customer service for more formulation optimization consultation services.
The purchasing partner is VITALIN Novate Biotech Group based in Munich, Germany, a leading mid-to-high-end brand deeply engaged in high-end anti-aging dietary products across Europe. Its products are sold in premium selected lines of German DM supermarkets, Swiss chain wellness clinics and Austrian private physical examination centers, with two flagship product lines: high-end compound NMN hard capsules and portable effervescent powder. Products comply with four stringent standards: EU EFSA dietary raw material control specifications, USP Pharmacopoeia, Clean Label clean label standards and German LFGB food raw material safety norms, targeting high-net-worth consumer groups across Europe. Previously, the brand sourced pharmaceutical-grade β-NMN from local German biopharmaceutical enterprises with an annual stable procurement volume of 28 tons.
Faced with shrinking local biochemical raw material production capacity in Europe, successive annual raw material price hikes and tight production scheduling, the brand’s R&D department planned to source enzymatic β-NMN raw materials from China, with an initial trial purchase of 4 tons for mass production and launch of new compound anti-aging products combining NMN, PQQ and ergothioneine in the European autumn market.
After independently sourcing off-the-shelf raw materials from three domestic NMN manufacturers, the client encountered four consecutive linked technical failures in powder processing adaptation, formulation incompatibility, raw material storage & transportation stability and insufficient terminal bioavailability. Factories could only produce raw materials per their own mass production standards, lacking formulation R&D capabilities to optimize raw material indicators from the perspective of finished product production, failing to resolve all technical pain points despite multiple sample adjustments. Mass production of new products was fully suspended, and the original European autumn new product launch schedule was delayed. Upon industry referral, the client fully entrusted HiSiaddi Foreign Trade to undertake full-chain technical diagnosis, raw material process rectification and formulation optimization implementation. Supported by HiSiaddi’s in-house raw material engineers and formulation R&D team, all technical pain points were resolved step by step from raw material physical and chemical improvement to terminal formulation debugging.
The client’s factory operates German imported fully automatic high-speed capsule filling production lines with strict raw material requirements: bulk density 0.50–0.56 g/cm³, angle of repose 33°±2°, particle size 120–150 mesh, excellent powder fluidity without excessive fine floating powder or agglomeration. Off-the-shelf generic crude crystalline β-NMN supplied by three domestic factories featured inconsistent bulk density ranging from 0.39 to 0.68 g/cm³, mixed coarse and fine particles with fine powder proportion exceeding 32%. During mass production, material hoppers frequently arched and blocked, requiring 3–4 shutdown cleaning sessions per hour; single capsule filling weight fluctuation error exceeded ±5%, far above the brand’s internal qualified standard of ±2%, rendering large batches of semi-finished products unavailable for subsequent processes and causing raw material losses exceeding 200kg per batch. Manufacturers stated mass production lines adopted fixed crystallization processes and could not independently adjust crystal morphology and screening specifications for small-batch orders, only supplying existing off-the-shelf grades without targeted powder parameter adjustment.
The client’s new product formulation blends four active raw materials: β-NMN, PQQ, L-ergothioneine and trimethylglycine, each with vastly different physical and chemical properties: NMN is highly hydrophilic and prone to moisture absorption, PQQ is sensitive to heat and humidity, and ergothioneine requires weak acidic storage environments. Domestic raw materials were not pre-treated for compound compatibility; direct mixing resulted in surface water absorption and agglomeration of mixed powder after 15 days of constant-temperature accelerated stability testing (40°C, RH75%). HPLC testing revealed a 7.8% drop in effective NMN content and 11.3% attenuation of PQQ content, failing to meet the mandatory 24-month shelf life standard of the EU. Domestic raw material manufacturers only control monomer raw material purity without experience in compound compatibility testing, unable to develop raw material modification schemes tailored to the formulation system.
β-NMN inherently undergoes rapid hydrolytic degradation under high temperature and humidity environments: natural loss of active ingredients can reach over 18% after one month of storage above 30°C and 60% humidity. The first batch of raw materials adopted generic food-grade inner bags + fiber drum packaging, with a 32-day ocean freight cycle from China to Hamburg. Shipping containers maintained long-term temperatures exceeding 38°C while transiting high-temperature Mediterranean sea areas. After arrival, barrel-opening sampling revealed partial raw material caking from moisture absorption, with average raw material content declining by 5.2% across the entire batch—failing to meet the brand’s warehousing acceptance threshold of ≥99.0% and resulting in raw material downgrade losses. Manufacturers retained generic warehousing and packaging schemes without familiarity with temperature and humidity fluctuations during cross-border ocean transportation, unable to customize moisture-proof modification and exclusive packaging solutions.
Per the brand’s high-end new product positioning, oral raw materials must maintain gastric acid degradation rate ≤35% to ensure effective absorption and conversion in the small intestine. Conventional unmodified domestic β-NMN undergoes rapid hydrolysis destruction of over 65% of ingredients under strong gastric acid conditions (pH 1.5–3.5), leaving less than 30% of absorbable active components reaching the intestinal tract. This conflicted with the product’s marketing positioning and European terminal clinical data, preventing approval for German supermarket product filing. Raw material manufacturers only monitor factory release purity indicators without research on in-vivo metabolism and absorption characteristics, lacking process reserves for coating modification to address insufficient bioavailability.
HiSiaddi dispatched raw material technical engineers to reside at factories for production optimization, adjusting processes starting from the crystallization stage:
1. Optimize enzymatic crystallization cooling curves, abandoning conventional constant-speed cooling and adopting three-stage gradient temperature-controlled crystallization (high-temperature pre-crystallization, medium-temperature crystal shape control, low-temperature shaping) to precisely regulate NMN crystal particle size at the source and narrow particle size distribution range.
2. Add sealed air flow grading and screening sections to remove excess fine dust and oversized agglomerates, locking finished particle size uniformly at 130 mesh.
3. Fine-tune drying negative pressure parameters to control finished product moisture ≤0.35%. Measured bulk density stabilized at 0.53 g/cm³ with an angle of repose of 34.1°, fully falling within the client’s equipment compatibility range. A 50kg post-rectification sample was sent to Germany for on-machine testing, achieving continuous 16-hour automatic filling without hopper blockage and capsule filling weight error stably controlled within ±1.3%, successfully passing mass production equipment verification.
Combining the physical and chemical properties of the four raw materials, HiSiaddi’s formulation team implemented two optimization solutions:
1. Raw material pre-treatment: Apply thin-layer coating modification on β-NMN with low-proportion HPMC (hydroxypropyl methylcellulose) to form a dense water barrier film, reducing NMN moisture absorption rate and isolating acid-base contact between raw materials. The modification additive proportion was strictly controlled at 1.8% without impacting raw material main content or Clean Label labeling eligibility.
2. Formulation ratio fine-tuning: Optimize the feeding sequence of four active raw materials, adjust the proportion of auxiliary materials (microcrystalline cellulose, anhydrous dibasic calcium phosphate), and replace conventional water-containing carriers with anhydrous moisture-proof auxiliary materials to avoid localized water vapor enrichment after mixing. After optimization, 60-day accelerated stability testing at 40°C/RH75% was re-conducted on mixed powder, showing no agglomeration or stratification, with attenuation of three active ingredients (NMN, PQQ, ergothioneine) all below 1.2%, meeting the EU’s 24-month shelf life control standard.
1. Add low-temperature nitrogen replacement sealed sub-packaging procedures at the end of raw material production; finished materials are immediately sealed under nitrogen protection after discharge to isolate water vapor contact with air.
2. Upgrade packaging to triple protection: food-grade aluminum foil vacuum inner bags + double-layer PE moisture-proof films + thickened moisture-proof fiber drums, with independent small desiccant packs installed inside drums. Simultaneously optimize storage and transportation specifications, requiring finished raw materials to be stored at a constant temperature of 22°C with humidity ≤45%. Subsequent batches of 4 tons of goods shipped from Shanghai to Hamburg via 33-day ocean freight achieved an average raw material content decline of only 0.72% upon barrel-opening sampling at destination, fully meeting warehousing acceptance standards.
Drawing on the latest EU EFSA research data on NMN digestive tract metabolism, HiSiaddi collaborated with factories to adopt low-temperature micro-enteric coating technology using plant-derived enteric carriers for thin-layer modification of β-NMN. Raw materials remain stable and insoluble under acidic gastric fluid conditions, gradually dissolving and releasing active ingredients under neutral small intestinal environments. Third-party in-vitro simulated gastric fluid testing showed the gastric acid degradation rate of modified NMN dropped from 67% to 31.2%, significantly increasing absorbable active components. Relevant in-vitro test reports were submitted to German importers to supplement local German product filing documents, meeting the bioavailability indicator requirements for high-end products.
After four rounds of sample iteration and process finalization, rectified customized β-NMN raw materials were delivered in bulk, with all 4 tons warehoused and put into mass production. The client’s new compound NMN products completed mass production on schedule and were launched on premium supermarkets across Germany and Switzerland. Terminal sales volume in the first quarter after launch rose by 27% year-on-year compared with the brand’s previous generation products, forming differentiated product advantages relying on raw material stability and high absorption efficiency.
After project delivery, the client fully recognized HiSiaddi’s full-chain technical service capacity, terminated local German raw material procurement, and signed an annual framework procurement contract for 28 tons with balanced monthly shipments split into seven batches. HiSiaddi fixed exclusive raw material grades and complete internal production control standards, continuously tracking minor raw material process adjustments and formulation iterations throughout the year. The client subsequently launched R&D of sublingual fast-dissolving NMN powder new products, fully entrusting HiSiaddi with raw material water solubility modification, auxiliary material screening and sample stability testing, placing successive additional customized orders for ultra-fine powder-grade NMN. HiSiaddi also established an exclusive technical archive for the client, tracking real-time updates to EU EFSA and German LFGB regulations, predicting early adjustments to raw material indicator control standards, and conducting two annual formulation stability reviews for the client.
Most domestic NMN raw material manufacturers operate on an off-the-shelf bulk sales model, designing production processes for mass-market generic products and only focusing on monomer content compliance. They generally lack technical reserves for downstream formulation R&D, refined powder modification and storage & transportation stability optimization, unfamiliar with parameters of automatic production lines for European and American high-end health products, compound formulation compatibility rules and EU shelf-life regulations. They can only passively market self-produced standard raw materials without reverse-optimizing raw material quality per terminal product demands of mid-to-high-end clients.
Mid-to-high-end dietary brands in Europe and America are bound to premium supermarkets and private medical institutions, subject to dual stringent control by drug regulatory authorities and channel operators. Any non-compliance in raw material physical and chemical properties, stability or absorption parameters directly leads to delayed new product launches, production line shutdowns or product removal from shelves, damaging brand reputation. Therefore, mid-to-high-end clients are willing to bear reasonable modification premiums and prioritize supply chain service providers capable of delivering full-chain technical support.
Breaking the traditional foreign trade intermediary model solely focused on raw material supply matching, HiSiaddi forms a closed-loop full technical service chain covering client technical pain point diagnosis → upstream raw material process technical transformation → coordinated formulation optimization → customized storage & transportation solutions → mass production verification. It bridges the information gap: domestic factories lack understanding of downstream formulation processes, while overseas clients lack familiarity with technical transformation capabilities of China’s raw material production industry. Relying on technical services, HiSiaddi deeply binds long-term repeat purchases from overseas mid-to-high-end clients, achieving win-win outcomes for both supply and demand sides.
Contact HiSiaddi customer service for more formulation optimization consultation services.
+86-13120989737 
info@hisiaddi.com 
English
