HiSiaddi is an innovative foreign trade service provider driven by dual engines of technology transformation and foreign trade services. It has established a "1+2+3+4=1" service system and can supply raw β-nicotinamide mononucleotide (β-NMN) sourced from multiple well-known original manufacturers. As a tech-driven foreign trade enterprise, HiSiaddi has repeatedly resolved customized product demands for β-NMN through technological transformation cooperation with factories and precise insight into market demands. Below is a case of HiSiaddi addressing customized requirements for β-NMN raw materials.
Contact HiSiaddi customer service for more customized service solutions.
The purchasing partner is LIVAGE Novigen Biotech Group based in California, USA, a mid-to-high-end benchmark brand deeply engaged in the high-end anti-aging dietary track across North America. Its full product line is sold in Whole Foods premium supermarkets across the US, high-end private health management clinics and premium wellness clubs in Southern California. Its core audience consists of high-net-worth middle-class and elite groups in North America, with two flagship product lines: high-potency NMN hard capsules and sublingual fast-dissolving powder. The product access standards align with four major systems: US USP Pharmacopoeia, FDA dietary supplement control specifications, Clean Label clean label standards and full cGMP production control. Previously, the brand imported pharmaceutical-grade β-NMN from Swiss biopharmaceutical factories with an annual stable raw material procurement volume of 45 tons.
Due to multiple adverse factors including shrinking local API production capacity in Europe and America, continuous surges in international raw material prices and uncontrollable delivery cycles for ocean freight, the brand’s R&D and procurement departments resolved to launch localized customization and sourcing in China, planning to develop exclusive customized raw material grades. The first trial customized order of 3.5 tons was scheduled for production and launch of new high-content anti-aging capsules.
The client independently visited five mainstream domestic NMN manufacturers in China in the early stage, yet all customized docking work hit a dead end. Most domestic manufacturers focus sales on mass-produced standard off-the-shelf products, prioritizing self-produced mass grades and low-cost raw materials synthesized via chemical routes. They showed minimal willingness to accommodate refined personalized customization requirements proposed by the brand. Some leading manufacturers with bio-enzymatic production lines either set a minimum customization order threshold of over 10 tons per batch, far exceeding the client’s small-batch trial production volume for new products, or could only make minor adjustments to existing mass production processes, failing to manufacture products fully compliant with the full-dimensional customized physical, purity, configuration and residue indicators specified by the US R&D team. All manufacturers could only provide domestic national standard test reports, lacking complete sets of foreign-language compliance dossiers, process traceability documents and test data from internationally recognized third-party laboratories required for US imports. Their R&D teams could not synchronize formulation debugging with the US formulation laboratory, delaying the client’s new product launch plan by over two months due to fruitless sourcing. Upon industry referral, the brand fully entrusted HiSiaddi to coordinate the full-chain customized implementation work, covering raw material process selection, special technical transformation of production lines, gradient sample iteration, physical and chemical indicator customization, supporting compliance documents and export customs clearance in a one-stop manner.
Drawing on over a decade of R&D accumulation in anti-aging products, combined with equipment parameters of the US terminal formulation production line, product formulation architecture and supermarket warehousing quality inspection specifications, the client issued a set of extremely stringent customized technical specifications, distinct from generic industrial-grade and food-grade off-the-shelf NMN raw materials available on the market. Five core mandatory customized clauses served as the benchmark for project delivery:
1. Configuration and purity customization: Only physiologically active β-configurations retained in finished products; HPLC-tested effective β-NMN content ≥99.90%; invalid α-chiral isomer impurity ≤0.08%; total impurities controlled within 0.1%, rejecting crude raw materials mixed with multiple configurations widely available in the market.
2. Mandatory production process requirement: Fully enzymatic catalytic biosynthesis route without benzene, halogenated hydrocarbons and other high-risk organic solvents throughout production, eliminating chemical synthesis processes to meet US Clean Label labeling requirements, allowing raw material origin marked as bio-enzymatic conversion on finished product ingredient lists.
3. Customized powder physical indicators: Split particle size standards tailored to the brand’s two differentiated production lines: capsule-grade raw materials with particle size ranging from 100 to 140 mesh, bulk density 0.52–0.58 g/ml, angle of repose 32°–36°, compatible with fully automatic high-speed capsule filling machines to avoid electrostatic agglomeration and hopper bridging blockage of powder; sublingual powder customized as ultra-fine 600-micron powder with 100% water solubility, no suspended solids or precipitation after cold water dissolution.
4. Safety limit customization: Single limit of four heavy metals (lead, arsenic, cadmium, mercury) <0.1 ppm; all organic solvent residues ND (not detected); total microbial count, mold and yeast, Salmonella and Escherichia coli fully compliant with USP microbial limit standards.
5. Supporting document customization: English COA, SDS, process traceability files and full-item test reports from US-recognized third-party laboratories attached to each batch of raw materials, supporting US FDA product filing and supermarket warehousing audits.
Before entrusting HiSiaddi to intervene, the client’s procurement and R&D staff contacted five domestic NMN manufacturers via cross-border exhibitions and raw material platforms, covering large chemical synthesis factories, ordinary fermentation raw material plants, mid-tier food raw material producers and a small number of enzymatic process specialized enterprises. Four common industry-wide bottlenecks emerged during communication, which are universal pain points hindering small-batch high-end customization of domestic NMN products.
1.
Inability to flexibly switch production processes Most leading domestic manufacturers allocate core production capacity to low-cost chemically synthesized NMN, with equipment, fermentation tanks and refining sections designed for mass chemical production processes. Factories refuse to adjust separate processes for small-batch 3.5-ton orders due to equipment, labor and R&D transformation costs, repeatedly persuading clients to switch to off-the-shelf chemically synthesized grades. Even manufacturers with enzymatic production lines prioritize mass bulk orders of ten-thousand-ton scale, pushing customized batch lead times to over 45 days, unable to match the client’s new product launch timeline.
2.
3.
Insufficient refined powder processing capacity Most off-the-shelf domestic NMN products adopt crude crystallization without precise grading and screening procedures, resulting in inconsistent particle sizes with excessive fine powder or oversized particles. Existing crushing and screening equipment cannot simultaneously produce two specifications: 100–140 mesh capsule-grade material and 600-mesh ultra-fine water-soluble powder. Factories refuse to bear equipment modification costs for additional air jet ultrafine crushing and precision grading equipment given limited order volume, only supplying single-size universal powder incompatible with the client’s two distinct formulation production lines.
4.
5.
Internal control standards only aligned with domestic national standards, failing to meet US USP limits Domestic manufacturers only test main content during factory release, generally ignoring chiral isomers, trace by-products, trace solvent residues and other critical indicators required for overseas formulations. Conventional factory testing equipment cannot accurately detect trace isomer impurities below 0.1%, and third-party entrusted testing only provides Chinese national standard reports without completing over 200 full-item English testing per US requirements. Manufacturers lack mature procedures for cooperating with internationally recognized third-party laboratories such as SGS and Intertek.
6.
7.
Lack of customized supporting services Traditional raw material factories operate on an off-the-shelf bulk sales model without teams specializing in foreign trade compliance or formulation technical support. They cannot compile complete English traceability dossiers per US regulations or cooperate with US laboratories for multi-gradient sample testing. Clients need multiple batches of samples sent in stages for formulation verification, yet most factories charge high fees for sample delivery with cumbersome batch allocation, extending single sample cycle to over one week and delaying R&D validation.
8.
Drawing on years of supply chain resources, compliance teams and formulation technology reserves in the nucleotide raw material industry, HiSiaddi abandoned the single raw material factory sales mindset, screened compatible production resources backward based on the client’s customized indicators, eliminated chemical synthesis capacity manufacturers, and selected two specialized biological manufacturers with pilot enzymatic production lines capable of flexible technical transformation. The capsule-grade and ultra-fine powder grades were developed separately, with project implementation divided into six links: sample R&D, production line technical transformation, three-gradient sample iteration, physical and chemical finalization, compliance support and customized packaging.
HiSiaddi’s technical team stationed at cooperating factory workshops collaborated with factory R&D engineers to carry out partial technical transformation of original enzymatic conversion production lines:
1. Optimize substrate feeding ratio, enzymatic reaction temperature and dynamic pH control parameters with fully sealed sterile reactions to reduce generation of ineffective α-configured by-products during reaction.
2. Revamp terminal crystallization sections, abandoning conventional constant-temperature crude cooling crystallization and adopting segmented gradient low-temperature crystallization to precisely control crystal morphology via cooling rate adjustment, laying a foundation for finished particle size control.
3. For ultra-fine powder grades, coordinate temporary activation of sealed air jet ultrafine crushing units in pilot workshops and independent dust-free grading sections to separate and produce two customized raw materials with distinct mesh sizes.
4. Upgrade vacuum low-temperature drying equipment and extend negative-pressure solvent removal procedures to completely eliminate trace organic solvent residues at the production source, locking three core indicators: impurities, residues and molecular configuration.
Adopt a three-stage sample testing rhythm: lab-scale samples → 25kg pilot batches → mass production trial batches to complete closed-loop verification of all indicators.
1. First round lab-scale sample phase: Adjust crystallization and drying parameters based on optimized processes to produce five parallel sample groups with simplified English test data air-shipped to the client’s US R&D laboratory. The client simultaneously conducted capsule filling, powder reconstitution and accelerated stability tests. After receiving US feedback on powder fluidity and dissolution rate details, HiSiaddi coordinated secondary fine-tuning of process parameters with the factory.
2. Second round 25kg pilot batches: Separately produce 120-mesh capsule-grade raw material and 600-mesh ultra-fine water-soluble powder. The client conducted small-scale production on its mass production equipment, verifying continuous 12-hour capsule filling without blockage and filling weight variation controlled within ±2%; the powder dissolved instantly in cold water without precipitation.
3. Third round mass production finalized samples: Fix complete production process parameters and internal control standards, finalizing two standardized grades: LIV-CAP capsule-specific β-NMN and LIV-POW powder-specific ultra-fine β-NMN, forming fixed process files to lock mass production standards for future orders.
HiSiaddi coordinated Intertek international third-party laboratories to conduct customized testing items in accordance with USP and US dietary raw material standards, covering 216 full items including content, chiral configuration, isomers, heavy metals, residual solvents, microorganisms and pesticide residues, with authoritative bilingual Chinese-English test reports issued for all items. Test results showed β-NMN content at 99.93%, α-isomer at 0.06%, all organic solvents not detected, and four heavy metal indicators all below 0.08 ppm—all parameters exceeding the client’s customized threshold. Reports were filed as core documents for subsequent US import filing.
Comply with US imported food packaging regulations by adopting double-layer packaging: food-grade aluminum plastic inner bags + moisture-proof fiber drums, with bilingual Chinese-English product information printed on drum surfaces, marking β-NMN chemical name, country of origin, batch number, shelf life, storage conditions and US import filing number to avoid customs detention risks caused by non-compliant labeling in the US. Assist factories in building an exclusive electronic English batch traceability ledger, archiving full-process documents from initial raw materials (nicotinamide, ribose feeding records) to reaction logs, crystallization parameters and factory release inspection data. Every raw material batch achieves full-chain traceability to meet US full food traceability act requirements.
HiSiaddi’s compliance team sorted out full qualification documents item by item per US dietary raw material access requirements: collate English system certificates of factory cGMP, ISO22000 and HACCP; compile complete English production process traceability dossiers, allergen control statements and product free sales certificates; update the latest 16-item English SDS safety data sheets per REACH regulations; standardize customs declaration documents including commercial invoices, packing lists and certificates of origin to ensure fully consistent data across all documents and avoid detention risks at destination ports due to inconsistent customs clearance paperwork.
After standardization, mass production of the 3.5-ton first batch of customized raw materials was launched, split into two grades for separate packaging and warehousing. HiSiaddi coordinated domestic customs declaration and international ocean freight booking, shipping directly from Shanghai Port to Long Beach Port in Los Angeles, tracking logistics and port clearance progress throughout, and pre-sending full compliance documents to the US importer for advance customs declaration.
The first 3.5 tons of customized β-NMN raw materials arrived smoothly at Los Angeles Port, passing customs clearance rapidly without inspection or detention thanks to complete compliance documents and authoritative third-party test reports. After warehousing, the client immediately launched mass production of new products. Both production lines met all production data standards, and the newly customized NMN capsules and sublingual powder were successfully launched on Whole Foods premium supermarkets across the US. Terminal sales volume in the first month after launch exceeded the brand’s expectations by 22%. High-purity bio-enzymatic clean-label raw materials formed differentiated product competitiveness, widening the gap with competitors using generic chemically synthesized raw materials in North America’s high-end anti-aging health product track.
Having verified the quality of Chinese customized raw materials and HiSiaddi’s full-chain service capacity through this customized project, the client formally signed a long-term annual framework procurement agreement for 45 tons, with balanced shipments split into six batches per the brand’s quarterly new product production schedule. The factory reserved an exclusive customized production line for the brand, permanently adopting fixed production standards for LIV-CAP and LIV-POW grades without mixing generic mass-produced raw materials. Compared with original Swiss imported raw materials, comprehensive procurement costs decreased by 33.7% after localized customization, significantly optimizing the brand’s product profit margin. The brand subsequently launched R&D of compound NMN+PQQ powder new products, fully entrusting HiSiaddi with raw material selection, customized sample development and pre-formulation debugging, placing successive additional orders for compound blended raw material customization.
In addition, HiSiaddi established an exclusive product archive library for the client, archiving process documents, full-item test reports and compliance qualification documents for every raw material batch. It regularly tracks updates to US FDA dietary regulations and USP Pharmacopoeia standards, providing early warning of indicator adjustment changes, and simultaneously assists the client in completing raw material filing for multiple new products with US local drug regulatory authorities and supermarket systems, eliminating additional costs of repeated customization and filing for the client.
From an industry perspective, China’s β-NMN raw material sector presents a clear polarization pattern: numerous small and medium-sized factories focus on low-cost chemically synthesized off-the-shelf products to seize low-end circulation markets at low prices; large-scale leading manufacturers prioritize ten-thousand-ton bulk mass orders with standardized off-the-shelf products as core revenue streams, generally neglecting small-batch refined customization demands from overseas mid-to-high-end brands. Restricted by equipment transformation costs, R&D investment and short-term profit margins, manufacturers are unwilling to conduct technical transformation per personalized client indicators. Meanwhile, the vast majority of raw material producers lack teams specializing in overseas dietary regulation research and formulation application R&D, focusing solely on raw material production without understanding terminal health product filling and sub-packaging process pain points, unable to reverse-optimize raw material physical properties from the formulation application end. This constitutes the core reason why overseas mid-to-high-end brands repeatedly encounter obstacles in localized customization in China.
For mid-to-high-end dietary brands in the US, whose products are sold via premium supermarkets and private clinics under dual strict supervision by US drug regulatory authorities and channel operators, raw material production processes, configuration purity, powder physical properties and safety residues are directly linked to terminal product filing, shelf access qualifications and repeat purchase rates. Generic off-the-shelf raw materials with uncontrollable parameters may lead to substandard finished product stability, product removal from shelves, scrapping and severe brand reputation damage. Therefore, brands are willing to bear reasonable customization premiums to lock exclusive customized raw material grades, and product differentiation is the core competitive advantage for mid-to-high-end brands to occupy market share.
As a third-party professional foreign trade service provider, HiSiaddi breaks the single business model of traditional intermediaries solely engaged in supply matching, forming a closed-loop full-chain service covering client customized demand decomposition → upstream factory production line technical transformation → multi-round sample R&D → third-party authoritative testing → full-chain compliance support → export customs clearance delivery. Drawing on professional capabilities spanning raw material production, formulation R&D and import & export compliance, it bridges the two-way information gap: domestic factories lack understanding of overseas regulations and terminal formulation processes, while overseas clients lack familiarity with China’s raw material production control and supply chain resources. As a neutral third party, HiSiaddi balances customized production costs, factory production scheduling and client quality requirements, binding long-term stable repeat purchases from overseas mid-to-high-end brands via full-chain customized technical services, achieving win-win results for both suppliers and buyers.
Contact HiSiaddi customer service for more customized service solutions.
+86-13120989737 
info@hisiaddi.com 
English
