HiSiaddi is an innovative foreign trade service provider driven by both technology commercialization and cross-border trading. It has built a "1+2+3+4=1" service system and can supply bromelain powder sourced directly from multiple well-known original manufacturers. As a foreign trader with independent R&D capabilities, HiSiaddi has repeatedly resolved customized production demands for bromelain powder by cooperating with factories on technology transformation and accurately capturing market demands. Below is a case study of HiSiaddi’s customized bromelain powder solution.
Please contact HiSiaddi customer service if you require more customized product services.
Purchaser: NutriElite Group, a leading premium nutrition enterprise based in California, USA. As a top mid-to-high-end dietary supplement brand across North America, its products are sold in all categories of premium organic supermarkets, chain pharmacies and offline wellness clinics nationwide in the US. The company focuses on three core product lines: post-operative repair enzyme capsules, compound gastrointestinal digestive nutrition powder, and sports rehabilitation dietary tablets. All products comply with US FDA GRAS standards, DSHEA dietary supplement regulations, Kosher certification requirements and EU E1101 additive specifications. The group historically sourced original bromelain powder from established enzyme manufacturers in Europe and America, with an annual procurement volume of 19 tons.
Surging overseas raw material prices and prolonged lead times prompted the client to launch localized customized raw material production in China. The client sent samples to four domestic bromelain manufacturers for trial production, yet all factories only mass-produced standard off-the-shelf grades with minor adjustments limited to carrier excipients. None could conduct targeted process customization per the client’s formula specifications, leading to failed sample testing across multiple rounds. Issues including abnormal capsule disintegration and drastic enzyme activity degradation during storage delayed the client’s new product launch plan. The client formally entrusted HiSiaddi’s foreign trade team to manage the full-cycle customized project covering raw material process R&D, iterative sample testing and compliance implementation.
Mandatory Custom Specifications Required by the Client (Unachievable with Standard Mass-Produced Commercially Available Grades for Mid-to-High-End Dietary Supplements)
1. Customized Precise Enzyme Activity: Calibrated at 1800 GDU/g (mainstream mass-produced commercial grades only offer two fixed specifications: 1200 GDU/g and 2400 GDU/g without intermediate precise grades). Batch-to-batch enzyme activity deviation is strictly controlled within ±4%, corresponding to a stable national standard enzyme activity of 900,000 U/g.
2. Restricted Raw Material Source: Extracted exclusively from fresh pineapple stems; mixing with pineapple peels or pomace is prohibited. Residual miscellaneous proteases and pectin impurities are tightly controlled to avoid interfering with the activity of amylase and lipase blended in compound capsules.
3. Customized Carrier Formula: Single carrier consisting of non-GMO corn maltodextrin; zero lactose, zero dairy-derived ingredients and no corn protein allergens, meeting clean label standards and infant supplementary food equivalent control criteria.
4. Customized Formulation Stability: Low-temperature microencapsulated powder. When hermetically stored at a constant temperature of 25°C for 24 months, retained enzyme activity ≥90%. Compatible with the client’s wet granulation and high-temperature tableting processes; enzyme activity loss after short-term exposure to 80°C during tableting is less than 8%.
5. Microbial & Heavy Metal Custom Specifications: Total aerobic count ≤100 CFU/g; four heavy metal indicators (lead, arsenic, cadmium, mercury) exceed the limit requirements set by the US Pharmacopeia (USP). CNAS-accredited and third-party SGS bilingual test reports are provided.
Four established domestic enzyme manufacturers prioritize mass production of standard bulk goods and are unwilling to bear special technical transformation costs for R&D, resulting in four core customization barriers:
1. Inability to lock precise enzyme activity: Grades either hit 2400 GDU/g (causing excessive capsule dosing and higher costs) or fall to 1200 GDU/g (resulting in finished products failing US dietary supplement labeling efficacy standards).
2. Raw material adulteration with peel scraps leads to high impurity levels. Compound capsules delaminate and clump after 30 days of storage.
3. Ordinary uncoated powder lacks thermal protection. Enzyme activity loss exceeds 35% under high-temperature workshop tableting conditions, resulting in a finished product shelf life of less than 6 months.
4. Carriers contain lactose and whey powder; trace milk protein is detected during allergen screening, failing US import pre-inspection. All manufacturers pressured the client to switch to their standard off-the-shelf grades and refused targeted process modifications. The client invested USD 12,000 in sample R&D with no valid results, putting the customized project on the verge of suspension.
HiSiaddi horizontally screened two manufacturers specializing in high-end plant enzyme customization. The five core client specifications were split into separate production nodes, and factories were coordinated to implement targeted technical renovations across four processes: fresh raw material control → membrane separation purification → low-temperature freeze-drying → microcapsule coating.
1. Raw Material Control: Signed fixed supply contracts with compliant pineapple plantations in South China. Only fresh harvested stems are accepted; peels and rotten fruit are rejected upon arrival to prevent impurity contamination from the source.
2. Extraction & Purification: A three-stage ultrafiltration and nanofiltration purification process removes pectin, miscellaneous proteins and by-products, precisely concentrating enzyme liquid and locking the baseline target enzyme activity by adjusting concentration ratios.
3. Drying & Modification: Vacuum low-temperature freeze-drying replaces conventional high-temperature spray drying to maximize natural enzyme activity retention. Subsequent composite coating with chitosan and pectin produces sustained-release microencapsulated powder, resolving high-temperature deactivation and storage degradation issues.
1. First Round Laboratory Samples (300g × 3 batches): The factory adjusted concentration parameters. HiSiaddi simultaneously shipped samples to the client’s US laboratory for benchmark testing. Initial samples showed large enzyme activity fluctuations, prompting further optimization of membrane filtration parameters.
2. Second Round Optimized Samples (2kg): Enzyme activity stabilized within the range of 1730–1860 GDU/g with a deviation controlled within 3.8%. No allergens were detected in carriers, and no caking or delamination occurred after compounding with the client’s formula in small batches.
3. Pilot Production (300kg): A full production line replication trial was completed. The client conducted full-process trial production on its tablet manufacturing line, recording 7.2% enzyme activity loss after 80°C tableting and 93.5% retained enzyme activity after 90 days of accelerated room-temperature storage. All specifications met requirements.
1. HiSiaddi assisted manufacturers in commissioning SGS to issue full-item Chinese-English bilingual test reports in accordance with US FDA and USP standards, supplemented GRAS filing documents, batch-specific Kosher certificates and ISO22000 system dossiers to meet US customs clearance and local pharmacy access inspection requirements.
2. Outer packaging was customized with English labels complying with US dietary supplement labeling laws, clearly indicating enzyme activity specifications, raw material sources, carrier components, allergen warnings and batch traceability codes to achieve full-chain traceability for individual batches.
A small trial order of 1.2 tons was delivered first and successfully cleared US customs. The client launched mass production of three complete post-operative repair capsule lines, with all terminal supermarket shelf inspection results fully compliant.
1. NutriElite Group (USA): Successfully completed localized customized replacement of bromelain raw materials. Comprehensive procurement costs decreased by 30.3% compared to European and American imported raw materials. Three new post-operative repair products relying on customized raw materials were launched, driving a 25% increase in sales across US local channels within six months and eliminating risks of rising overseas raw material prices and uncontrollable delivery cycles.
2. Domestic Custom Manufacturer: Established a fixed mass production process exclusive to the 1800 GDU grade bromelain via this benchmark North American high-end order. Premium customized products command a 36% premium over standard bulk goods, subsequently attracting customized inquiries from two high-end nutrition enterprises in Canada and Australia.
3. HiSiaddi Foreign Trade Service Provider: Established a high-end enzyme customization service model covering "spec disassembly – customized raw material technical transformation – multi-round sample follow-up – international compliance support", consolidating its market position in customized foreign trade of dietary supplement raw materials for North America.
Most domestic bromelain manufacturers focus on mass production of standard bulk goods and allocate limited R&D resources to standardized products, lacking refined targeted customization capabilities for mid-to-high-end overseas nutrition enterprises. European and American high-end dietary supplements feature strict formula requirements with personalized customization thresholds for enzyme activity, purity, carrier composition and stability. Drawing on expertise in overseas regulatory frameworks and enzyme application technology, HiSiaddi acts as a neutral intermediary linking supply and demand, driving targeted technical transformation at factories to develop exclusive product grades. The solution reduces raw material costs for overseas mid-to-high-end clients through localized customization while helping domestic manufacturers escape low-price competition and access the global high-end nutrition supply chain, achieving a win-win-win outcome for purchasers, manufacturers and foreign trade service providers.
Please contact HiSiaddi customer service if you require more customized product services.
+86-13120989737 
info@hisiaddi.com 
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