HiSiaddi is an innovative foreign trade service provider driven by both technology transformation and foreign trade services. It has established a "1+2+3+4=1" service system and can supply raw materials of Coenzyme Q10 from multiple well-known original manufacturers.
As a technology R&D-oriented foreign trade enterprise, HiSiaddi has repeatedly proposed formula optimization schemes and application improvement suggestions for Coenzyme Q10 products through technological transformation cooperation with factories and accurate insight into market demands. Below is a case of HiSiaddi’s formula optimization consulting service for Coenzyme Q10 products.
If you need more formula optimization consulting services, please contact HiSiaddi customer service.
BioSpa Biological Laboratory based in Madrid, Spain, has been deeply engaged in the high-end salon skincare market across the Iberian Peninsula for 27 years with its own GMP sterile filling factory. Its core products include post-procedure repair ampoules, organic anti-aging creams and high-concentration antioxidant essences. Previously, the brand consistently imported Japanese pharmaceutical-grade Coenzyme Q10 raw materials. To cut raw material costs and shorten delivery cycles, it began bulk procurement of three types of domestic Coenzyme Q10 in the second half of 2025: 99.8% high-purity crystalline powder, 10% organic vegetable oil dispersion liquid and phospholipid nano-encapsulated stock solution, with an annual total procurement volume of 6.8 tons.
After raw materials arrived at the warehouse and were put into production, four fatal formula and mass production failures broke out across the three production lines. A total of 1,200kg of semi-finished products already manufactured suffered quality abnormalities, forcing a 45-day delay in the new product launch.
The customer previously cooperated directly with two domestic raw material factories, which could only guarantee qualified COA data upon raw material delivery. Lacking downstream formula application engineers, the factories could only provide raw material parameters and failed to diagnose problems from three dimensions: raw material modification, formula adaptation and production technology. The factories insisted raw materials met standards and attributed failures to the customer’s formula and production operations, leading to mutual buck-passing. Upon recommendation from domestic raw material industry resources, the brand’s R&D director fully entrusted HiSiaddi, a foreign trade technical service provider, to conduct full-process technical diagnosis, raw material optimization, formula rectification and standardized mass production process implementation. HiSiaddi is staffed with cosmetic raw material engineers, formulation engineers and stability evaluation specialists, maintaining neutrality without affiliation to any single raw material factory.
The customer’s organic anti-aging cream adopted a cold low-temperature blending process with 0.08% high-purity Coenzyme Q10 powder added. Fine yellow crystals precipitated inside the cream after 20 days of room-temperature storage, leaving a gritty granular texture when applied. After 3 high-low temperature cycles (-15°C to 48°C), the entire formulation broke emulsification and separated water.
Root Cause: The 99.8% high-purity powder features high crystallinity. Coenzyme Q10 has strong liposolubility yet low solubility at room temperature. Trace residual solanesol by-products and homologous Q9 impurities in raw materials show poor compatibility with organic squalane carriers in the formulation, triggering crystallization at low temperatures during storage. European original raw materials underwent microcrystallization pretreatment to break coarse crystal structures, while domestic raw materials lacked microcrystal refinement treatment.
The stock solution uses organic sunflower oil as the carrier. When compounded with prototype VC and grape seed polyphenols to make essences, the product turned from orange-yellow to dark brown within 15 days after filling. Coenzyme Q10 active content plummeted from 98.2% to 56.7%, drastically weakening antioxidant efficacy and failing to meet the salon-grade 24-month shelf-life standard.
Root Cause: Coenzyme Q10’s quinone structure is susceptible to oxidation triggered by oxygen and trace heavy metals. Domestic stock solutions only rely on simple dissolution in vegetable oils without a natural synergistic antioxidant system. Trace heavy metal (lead, arsenic) levels exceeded standards by 0.06–0.09ppm, with metal ions catalyzing oxidation reactions. Prototype VC is strongly reducing and undergoes redox reactions with free Coenzyme Q10, destroying its molecular structure.
Ampoule formulations adopting nano-encapsulated Coenzyme Q10 recorded an in-vitro Franz transdermal penetration rate of only 19.2%, far below the 37.5% penetration rate of Japanese imported raw materials. Clinical feedback from offline clinic human trials indicated weak repair efficacy, failing to pass Spanish medical aesthetic clinical acceptance. Meanwhile, the stock solution experienced vesicle rupture and delamination during long-distance ocean shipping, with particle size surging above 200nm and encapsulation structure failure.
Root Cause: Domestic factories adopted conventional high-pressure homogenization without precise control of homogenization pressure and cycle times, resulting in a wide particle size distribution span (35–120nm) and fusion/rupture of small vesicles. Ordinary soybean phospholipids without cholesterol membrane stabilizers were used as phospholipid raw materials, and temperature fluctuations and vibration during ocean shipping caused rupture of lipid membranes and leakage of internal active ingredients.
The customer followed feeding practices for ordinary skincare raw materials, adding Coenzyme Q10 raw materials after heating the aqueous phase to 82°C, leading to sharp activity decline instantly upon feeding and high scrappage rates of full batches of semi-finished products, spiraling production costs out of control.
Root Cause: Coenzyme Q10 is heat and light sensitive, with accelerated oxidative degradation upon prolonged exposure to temperatures above 50°C. Domestic raw material packaging lacked nitrogen-filled light-proof sealing, and exposure to air upon opening in the workshop accelerated activity loss. The customer had no standardized SOP for low-temperature feeding.
HiSiaddi’s engineer team was stationed at both domestic raw material factories and the customer’s Spanish laboratory, optimizing upstream raw material physical and chemical indicators while rectifying downstream formulas and mass production processes. A three-in-one rectification plan combining raw material modification, formula fine-tuning and standardized production was adopted.
1. Raw material modification optimization: Coordinated the supplier factory to add air jet pulverization microcrystallization procedure on top of the original three-stage low-temperature recrystallization, refining coarse Coenzyme crystals to below 5μm to break regular crystal structures and improve solubility in vegetable oils. An advanced activated carbon impurity removal section was added at the final stage to strictly control total homologous Q9/Q11 impurities <0.25% and single heavy metal content <0.04ppm, complying with Ecocert organic raw material limits.
2. Customer formula fine-tuning: 0.5% natural candelilla wax was added to the original cream oil system. The network structure of plant wax anchors Coenzyme Q10 microcrystals to inhibit low-temperature precipitation, retaining the customer’s original organic formula framework without adding synthetic artificial emulsifiers to meet organic product labeling requirements.
3. Stability verification: After optimization, samples passed 6 rounds of high-low temperature cycle tests with no crystallization or delamination after 30 days of -18°C refrigeration, delivering smooth cream texture free of granular particles.
1. Upgraded raw material carriers: Bulk ordinary sunflower oil was replaced with EU organic-certified cold-pressed virgin sunflower oil complete with full-chain organic traceability reports. A composite antioxidant system of rosemary extract + natural vitamin E (3:1 ratio) was added to the stock solution without artificial antioxidants such as BHT, aligning with organic raw material requirements.
2. Compatibility formula optimization: The prototype L-ascorbic acid in the formula was replaced with stable VC derivative AA2G (ascorbyl glucoside) to avoid redox conflicts with Coenzyme Q10 caused by strong reducing agents. The final pH value of finished products was adjusted to 5.3–6.1 to avoid the acidic range where Coenzyme Q10 is prone to oxidation.
3. Accelerated aging test: After 90 days of constant-temperature storage at 45°C, no obvious darkening of sample color was observed, with Coenzyme Q10 activity retention ≥91.5%, meeting the 24-month shelf-life standard.
1. Rectification of factory production processes: Medicinal refined lecithin + cholesterol composite vesicle materials (phospholipid: cholesterol = 9:1) were adopted to enhance lipid membrane toughness. High-pressure microfluidizer homogenization parameters were optimized: homogenization pressure 1100bar, 5 circulation passes, precisely locking vesicle particle size at 40–70 nm with particle size distribution RSD <15% and strictly controlled encapsulation rate ≥93%.
2. Storage and transportation protection optimization: Finished stock solutions were filled into brown light-proof ampoules with nitrogen replacement deoxygenation sealing inside cans to prevent oxygen infiltration and vesicle rupture during ocean shipping. A cold chain transportation scheme with constant container temperature of 15–22°C was adopted for ocean freight.
3. Re-test of transdermal performance: After optimization, the in-vitro transdermal penetration rate rose to 38.1%, matching the performance of Japanese imported raw materials and successfully passing Spanish third-party clinical patch tests and repair efficacy assessments.
1. Mandatory feeding node rules: Coenzyme Q10 must be fed at an aqueous phase temperature ≤38°C. High-purity powder is pre-dissolved in low-temperature buffer oil before slowly adding to the emulsification system; direct dry powder feeding into high-temperature materials is prohibited.
2. Workshop production control: All feeding and homogenization procedures are carried out under light-shielded conditions with strong UV lighting switched off in the workshop. Opened raw materials must be fully consumed within 2 hours; unused residual raw materials are backfilled with nitrogen and sealed. Light-proof vacuum aluminum foil packaging is adopted for split filling.
3. Staff implementation training: HiSiaddi remotely guided the customer’s production team on practical operations, compiling bilingual Chinese-English feeding operation manuals for unified execution across the entire workshop. Activity loss during feeding dropped from 28% to below 3%.
1. Cross-border sample testing: 100g samples of each optimized raw material were airfreighted to the Spanish laboratory. The customer conducted full evaluations matching its proprietary finished product formulas, with all four indicators (purity, stability, compatibility, transdermal performance) passing inspection.
2. Pilot mass production verification: 500kg pilot batches of each specification were shipped to Madrid by sea. The customer carried out small-batch filling of three finished product lines, passing 3-month shelf-life aging tests, human sensitive skin tests and Ecocert organic raw material pre-audit with full acceptance.
3. Phased fulfillment of annual orders: The total 6.8-ton order was split into 8 batches for monthly delivery, breakdown as follows: 2.5 tons of high-purity crystalline powder, 2.3 tons of organic vegetable oil stock solution, 2.0 tons of nano-encapsulated stock solution. Prior to each batch shipment, HiSiaddi coordinated third-party sampling inspection, with each batch accompanied by English full-spectrum COA, SDS and raw material safety assessment reports.
1. The 1,200kg scrapped semi-finished products from the earlier batch were recovered and re-filled via formula fine-tuning, reducing raw material losses of approximately 93,000 Euros. The comprehensive procurement cost of optimized domestic Coenzyme Q10 decreased by 32.5% compared with Japanese original imports. New products were launched as scheduled across over 220 private medical aesthetic clinics in Spain, with revenue of the antioxidant product line surging 40.2% year-on-year in the first quarter after launch.
2. The brand renewed a 7.6-ton annual procurement framework contract the following year, entrusting HiSiaddi to coordinate domestic raw material selection and technical implementation for high-end antioxidant raw materials including resveratrol and ergothioneine.
Relying on this Spanish high-end salon rectification case, standardized production SOPs for three grades of high-end Coenzyme Q10 were established, improving internal control standards for microcrystalline Coenzyme Q10, antioxidant organic stock solutions and stable liposome products. With this qualified implementation case, the factories successfully secured orders from organic skincare brands in Portugal and Greece, achieving a 31% export premium for high-end customized grades and escaping low-price homogeneous competition in the domestic market.
A complete technical service system covering Coenzyme Q10 raw material defect diagnosis → targeted raw material modification → downstream formula optimization → mass production process implementation → full stability evaluation was established, alongside databases of compatibility taboos for liposoluble active raw materials and adaptation schemes for European and American organic salon formulas. Subsequent orders for technical supporting services of Coenzyme Q10 raw materials from mid-to-high-end cosmetic brands in Switzerland and Italy were secured.
1. Mid-to-High-End Overseas Brand Perspective: European and American organic salon formulations impose far stricter requirements on raw material crystal form, impurity content, carrier source and encapsulation technology than general daily chemical products. Imported brands are accustomed to high standard parameters of Japanese raw materials, and blind mass production using generic domestic off-the-shelf raw materials easily triggers mass failures including crystallization, oxidation and insufficient transdermal penetration. Overseas formulators’ lack of awareness regarding technical shortcomings of domestic raw materials is the primary inducement of failures.
2. Domestic Raw Material Factory Perspective: Most Coenzyme Q10 manufacturers focus on mass production of low-cost generic goods, only controlling purity indicators upon delivery without downstream formulation application R&D capacity, failing to identify compatibility shortcomings of raw materials in end-use formulas. Layout of customized modification technologies such as microcrystallization, lipid encapsulation and natural stabilization is mandatory to enter the European mid-to-high-end supply chain.
3. Product Technical Logic: Coenzyme Q10’s inherent physical and chemical properties (light sensitivity, heat sensitivity, poor water solubility, oxidation catalyzed by heavy metals) mean low-cost mineral oil carriers, conventional crystallization and extensive homogenization processes for generic bulk products cannot be adopted for mid-to-high-end applications. Coordinated optimization from three dimensions (raw material, formula and production) is required.
4. Core Value of HiSiaddi: As a neutral third party, HiSiaddi bridges technical barriers between upstream raw material factories and downstream overseas formulation teams. It urges factories to conduct targeted technical transformation and raw material optimization while assisting customers in formula adjustment and standardized production procedures, balancing conflicts between raw material production costs and end-use formula requirements. It acts as a critical technical link for domestic functional raw materials to enter overseas high-end salon markets.
If you need more formula optimization consulting services, please contact HiSiaddi customer service.
+86-13120989737 
info@hisiaddi.com 
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