HiSiaddi is an innovative foreign trade service provider driven by dual engines of technology transformation and foreign trade services, with a "1+2+3+4=1" service system and supply channels for original factory compound NSP enzymes from multiple well-known brands.
As a foreign trade enterprise with R&D capabilities, HiSiaddi has repeatedly proposed formula optimization plans and application improvement suggestions for compound NSP enzymes through technological transformation cooperation with manufacturers and precise market insight. Below is a consulting case of HiSiaddi’s formula optimization for compound non-starch polysaccharide enzymes.
Please contact HiSiaddi customer service for more formula optimization consulting services.
The cooperating client is Agravis from Germany, one of Germany’s largest high-end feed and agricultural technology groups. Its core businesses cover high-end livestock and poultry premixes, organic feeds and low anti-nutritional factor formula feeds, sold to high-end markets across Germany, Austria and Switzerland, serving large-scale organic pastures and precision breeding bases. The company strictly complies with EU FAMI-QS, EFSA, GMP+, non-GMO and traceability standards, with a technical team consisting of animal nutrition PhDs, bioengineering specialists and process engineers. Its requirements for enzyme formulation scientificity, thermal stability, application adaptability and data traceability reach research-grade standards.
In February 2026, the client purchased universal compound NSP enzymes (xylanase + glucanase + cellulase) for corn-soybean-miscellaneous meal broiler diets. Post-production, three major technical issues emerged: feed viscosity rose instead of falling, residual enzyme activity after pelleting dropped to only 35%, and broiler FCR showed no improvement, triggering a surge in pasture complaints. After investigation, the client’s technical team confirmed root causes as unbalanced formulation ratios, defective heat-resistant processes and mismatched application parameters, yet failed to pinpoint exact sources or optimization directions. Two domestic manufacturers contacted only provided standard formulas and general parameters, refusing in-depth technical breakdown and optimization, stalling the client’s project. The client urgently commissioned HiSiaddi to complete technical diagnosis, formula optimization, process adjustment and application solution delivery within 20 days; failure would result in termination of all China procurement.
Original factory generic formula: 8,000 U/g xylanase + 2,000 U/g β-glucanase + 1,500 U/g cellulase.
Diet characteristics: 65% corn + 20% soybean meal + 8% cottonseed meal + 7% rapeseed meal, with primary anti-nutritional factors at 5.8% arabinoxylan, 1.5% β-glucanase, 1.2% mannan and 1.0% pectin, with soluble NSP accounting for a high 3.5%.
Technical pain point: Excess cellulase (1,500 U/g), insufficient xylanase activity, lack of mannanase and pectinase. Excessive cellulase degrades beneficial fibre and releases large quantities of viscous oligosaccharides; insufficient xylanase cannot break down core viscous arabinoxylan; missing mannanase/pectinase leaves anti-nutritional factors in miscellaneous meals undegraded, ultimately raising digesta viscosity by 28% and hindering intestinal peristalsis.
Client process: High-temperature pelleting (85°C for 3 min) + post-conditioning (75°C for 10 min), with a minimum residual enzyme activity requirement of 70%.
Defects of original products: Non-heat-resistant strains, no microencapsulation protection and thermally unstable carriers. Xylanase from conventional strains rapidly inactivates above 80°C; lack of encapsulation exposes enzyme proteins to direct denaturation under high temperature and pressure; ordinary corn starch carriers gelatinize at 85°C and destroy enzyme structures.
Measured data: Post-pelleting residual activity reached only 32% for xylanase, 38% for β-glucanase and 41% for cellulase, averaging merely 35%. Insufficient effective enzyme activity eliminated all expected efficacy.
Production issues: Poor powder flowability, heavy dust and caking; manual addition of 25kg bulk bags leads to mixing uniformity CV >20%, causing local over- or under-dosage of enzymes.
Application issues: Fixed dosage of 1kg per ton feed without dynamic adjustment based on raw material batch fluctuations, animal age or seasonal changes; narrow pH adaptation range (only pH 5.5–6.5), resulting in nearly zero enzyme activity in broiler crops (pH 4.5–5.0) and caeca (pH 7.5–8.0).
Consequence: FCR fluctuations of 0.15 across pastures, with zero efficacy in some farms and elevated diarrhoea rates in others; the client’s technical team could not explain inconsistent performance.
HiSiaddi assembled a technical team including enzyme formulation PhDs, thermal stability specialists, feed process engineers and animal nutrition consultants, cooperating with domestic specialized enzyme R&D and production bases. We followed a six-step workflow: technical diagnosis → formula reconstruction → thermal performance upgrade → process optimization → customized application solutions → lab trial verification, with full data-driven breakdown, precise optimization and visual validation. The client’s technical team participated throughout and received real-time data updates.
1. Formula diagnosis: Actual activity values, enzyme ratios and substrate specificity testing of original enzymes confirmed cellulase overdosage by 3 times, xylanase activity deficit of 40% and missing mannanase/pectinase.
2. Thermal stability diagnosis: Simulation of client 85°C/3 min pelleting process confirmed conventional strain xylanase half-life <1 min at 85°C, with over 60% activity loss without encapsulation protection.
3. Application diagnosis: Testing of enzyme activity across pH 4.0–8.0, powder flowability and mixing uniformity revealed a narrow pH adaptation window, poor powder flowability (angle of repose >45°) and mixing CV >20%.
4. Diet diagnosis: Analysis of NSP composition in client corn-miscellaneous meal diets identified core degradation targets: arabinoxylan, mannan and pectin, with restricted cellulose degradation required.
Based on diagnostic results, we fully reconstructed the formula adopting a synergistic combination of high-activity xylanase + mannanase + pectinase + medium-activity β-glucanase + low-activity cellulase, with accurately calibrated enzyme activity units:
· Xylanase (endo + exo, heat-resistant strain): 12,000 U/g (50% activity increase, targets core arabinoxylan degradation)
· β-glucanase (neutral heat-resistant type): 2,500 U/g (25% activity increase, compatible with intestinal pH)
· Mannanase (high specific activity): 3,000 U/g (newly added, breaks down mannan in miscellaneous meals)
· Pectinase (high-methoxy type): 2,000 U/g (newly added, degrades miscellaneous meal pectin)
· Cellulase (restricted neutral type): 500 U/g (67% reduction, only degrades non-beneficial fibre and protects useful dietary fibre)
Core logic: Targeted degradation of high-viscosity NSPs, supplementation of missing enzymes, balanced synergistic effects and prevention of excessive fibre breakdown.
Lab trial verification: When incorporated into client diets, the optimized formula reduced digesta viscosity by 35% (from 420 mPa·s to 273 mPa·s), lifting soluble NSP degradation rate from 32% to 68% and significantly improving intestinal environment. The client’s technical team reviewed and confirmed the formula is scientifically sound, highly targeted and delivers remarkable synergistic effects, fully matching corn-miscellaneous meal diet characteristics.
HiSiaddi deployed three core heat-resistant technologies to completely resolve high-temperature pelleting activity loss:
1. Fermentation with heat-resistant strains: Xylanase produced via heat-mutated Bacillus licheniformis, boosting molecular thermal stability by 40% and extending 85°C half-life to 5 minutes.
2. Double-layer microencapsulation: Inner high-temperature-resistant starch layer (gelatinization temperature >90°C) + outer cross-linked sodium alginate-calcium salt layer, maintaining ≥92% encapsulation integrity after 85°C/3 min treatment to shield enzyme proteins from thermal denaturation.
3. Low-temperature post-processing + heat-resistant carriers: Low-temperature concentration of fermentation broth (45°C) + spray drying (inlet air 150°C / outlet air 70°C) to avoid activity loss; carrier blend of silicon dioxide + high-temperature-resistant corn starch that resists gelatinization and caking at 85°C.
Lab trial verification: Simulating the client’s 85°C/3 min pelleting process, the optimized product retained 78% xylanase, 74% β-glucanase, 76% mannanase, 73% pectinase and 71% cellulase activity, with average residual activity ≥75%, far exceeding the client’s 70% minimum standard.
1. Powder characteristic optimization: Adjusted carrier ratio (15% silicon dioxide + 85% corn starch) with food-grade anti-caking agents, reducing powder angle of repose to 32°, drastically improving flowability, cutting dust generation by 60% and eliminating caking.
2. Improved mixing uniformity: Supplied 1kg small bags compatible with the client’s automatic feeding system, paired with a pre-mixing protocol (pre-blend with 5% corn flour before incorporation into main feed) to lower mixing uniformity CV below 8%.
3. Widened pH adaptation range: Screening of acid-alkali tolerant enzymes extended the pH working window to 4.5–7.5, covering the full broiler digestive tract (crop, stomach and intestines) to sustain high activity throughout digestion.
4. Customized dynamic dosing scheme: Provided a variable dosage table of 0.8–1.2kg per ton feed, adjusted based on raw material batches (corn/miscellaneous meal NSP content), broiler age (chicks/mature birds) and seasons (high/low temperature) to match real-world production demands.
Parallel controlled trials were conducted on two core client pastures with 150,000 broilers:
· Control group: Original universal enzyme (1kg per ton feed)
· Test group: HiSiaddi optimized enzyme (1kg per ton feed, dynamically adjusted)
Test indicators measured: Digesta viscosity, post-pelleting residual enzyme activity, FCR, mortality rate and faecal viscosity.
Test Results (All Indicators Met or Exceeded Targets)
表格
Test Indicator | Control Group (Original Enzyme) | Test Group (HiSiaddi Optimized Enzyme) | Improvement Effect |
Digesta Viscosity (mPa·s) | 420 | 273 | -35% |
Average Post-Pelleting Residual Enzyme Activity | 35% | 75% | +114% |
Broiler FCR (21–42 Days Old) | 1.85 | 1.78 | -3.8% |
Mortality Rate | 3.2% | 1.8% | -43.8% |
Faecal Viscosity Grade | High (Grade 3) | Low (Grade 1) | Significant Improvement |
The client’s technical director reviewed the data on-site and confirmed all indicators passed standards, with FCR improvement exceeding expectations, completely resolving all technical pain points of the original product.
1. Unbalanced formulation: Reconstructed targeted synergistic formula cutting digesta viscosity by 35%.
2. Pelleting activity loss: Heat-resistant strains + double-layer encapsulation delivering ≥75% residual enzyme activity post-pelleting for sufficient effective activity.
3. Unstable application performance: Optimized powder properties + dynamic dosing scheme enabling uniform mixing, full-intestinal activity and consistent efficacy, with inter-pasture FCR fluctuations limited to ≤0.05.
In March 2026, the first batch of 10 tons of optimized compound NSP enzymes entered mass production and delivery, accompanied by English technical reports, enzyme activity test reports and application guidelines for every batch. HiSiaddi provides lifelong technical services including regular pasture visits, data testing and dynamic formula/dosing adjustments for full-cycle technical support.
The client designated HiSiaddi as its exclusive technical partner and core supplier with an annual procurement volume of 80 tons. Joint development of specialized NSP enzymes for ruminants and low-allergen enzymes for organic feed is planned through a joint EU feed enzyme technology laboratory co-established with HiSiaddi.
Quote from the Client Technical Director: "HiSiaddi is the only technically capable partner in China that can resolve core problems for us. Most Chinese manufacturers only sell products without technical expertise or in-depth diagnosis and optimization capabilities. HiSiaddi boasts a professional team of formulators, thermal stability specialists, process engineers and animal nutrition consultants, who accurately diagnosed and fully resolved our long-standing formulation, heat resistance and application bottlenecks within 20 days with solid data and outstanding efficacy supported by professional services. They serve as our core technical backbone for securing high-quality supplies from China’s supply chain."
For foreign mid-to-high-end clients purchasing compound NSP enzymes, technical pain points extend far beyond pricing, centering on three high-end technical barriers: formulation scientificity, thermal stability and application adaptability.
· Low-end clients: Focus solely on price and initial enzyme activity, accepting universal standard products while ignoring technical details.
· Mid-to-high-end clients: Require precise diet matching, high-temperature pelleting tolerance, full-intestinal high activity, uniform mixing, stable and traceable efficacy, and are willing to pay reasonable premiums for professional technical services and consistent high quality.
HiSiaddi’s core value lies in an integrated three-in-one capability: R&D Technology + Supply Chain Integration + Customized Services.
1. Technology: PhD-level formulation team, thermal stability specialists, process engineers and animal nutrition consultants capable of in-depth technical diagnosis, targeted formula reconstruction, thermal process upgrades and customized application solutions.
2. Supply Chain: Cooperation with specialized enzyme production bases to deliver full-cycle technical implementation across lab trials, pilot trials and mass production, with strict control of batch stability and product quality.
3. Services: Lifelong technical support, dynamic formula optimization and data tracking reviews to fully resolve client technical pain points throughout the application lifecycle.
Please contact HiSiaddi customer service for more formula optimization consulting services.
+86-13120989737 
info@hisiaddi.com 
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