HiSiaddi is an innovative foreign trade service provider driven by dual engines of technology commercialization and foreign trade services. We have established a "1+2+3+4=1" service system and can supply raw materials of sodium hyaluronate from multiple well-known original manufacturers.
As a technology-driven foreign trade enterprise, HiSiaddi has repeatedly proposed formula optimization schemes and application improvement suggestions for sodium hyaluronate products through technological cooperation with manufacturers and precise insight into market demands. Below is a consulting case of HiSiaddi on formula optimization for sodium hyaluronate products.
If you need more formula optimization consulting services, please contact HiSiaddi customer service.
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Partner Client: Barcelo Derm High-End Medical Aesthetic Laboratory, Spain A mid-to-high-end enterprise dedicated to the R&D and production of post-aesthetic repair serums, sterile aqua light stock solutions and superficial soft tissue filling gels for European beauty clinics. Its products comply with the European Pharmacopoeia (EP), EU SCCS standards and EC1223 cosmetic regulations, supplying over 200 private medical aesthetic clinics and high-end pharmacies across Spain, Portugal and Andorra. The client previously purchased imported HA raw materials from local Spanish suppliers. To cut procurement costs, it selected domestic pharmaceutical-grade sodium hyaluronate with an annual procurement volume of 35 tons, divided into two categories: ultra-low molecular weight oligomeric HA and medium molecular weight injectable HA.
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Core Cooperation Conflicts After the client purchased raw materials directly from domestic manufacturers and put them into production, four consecutive technical failures emerged: precipitation during formula compatibility, powder caking during dissolution, molecular weight degradation under high-temperature homogenization and yellowing oxidation of finished products during storage. Multiple production lines were suspended, nearly 400kg of semi-finished products were scrapped, and the new product launch was delayed. Manufacturers could only optimize basic indicators of their own raw materials and failed to deliver targeted improvements combining the client’s terminal formulas and European production equipment. The client entrusted HiSiaddi to fully conduct technical diagnosis, formula improvement and production process optimization.
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Positioning of HiSiaddi’s Services A foreign trade + technical service provider linking upstream raw material R&D, third-party testing laboratories and the client’s formula R&D department to deliver a complete solution covering raw material fine-tuning, formula optimization and workshop production process adjustment.
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Dry powder agglomeration and pipeline blockage Domestic HA powder features a wide particle size range with an excessively high proportion of ultrafine powder. The client retained the feeding method used for European raw materials (direct pouring into clean water). The powder quickly swelled on contact with water to form a gel film encapsulating internal dry powder, leading to large-scale agglomeration. Negative pressure feeding pipelines frequently clogged. Manual crushing of agglomerates introduced fine impurities, causing frequent blockages of filter elements in precise filtration procedures for stock solutions and cutting production efficiency by 50%.
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High-temperature high-speed homogenization triggering chain scission and degradation of high-molecular HA The client’s original European customized HA delivered excellent heat and shear resistance, with mass production conducted at 78℃ combined with high-speed homogenization. Domestic raw materials exhibited weaker thermal stability; under identical processes, macromolecular chains fractured, leading to a 16%~21% drop in measured molecular weight of medium molecular weight materials. Batch viscosity fluctuations of finished products exceeded standards, resulting in insufficient viscosity of aqua light stock solutions that failed to meet clinical salon requirements.
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The client lacked a compatibility database for domestic HA and could not adjust auxiliary material ratios based on raw material physicochemical indicators, leading to repeated sampling that wasted raw materials and extended R&D cycles. Manufacturers could only issue national standard test reports, lacking segmented indicators (molecular weight distribution PD, free protein, endotoxin itemized data) required for European formula optimization reference.
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White flocculent precipitation in HA + L-Ascorbic Acid + Niacinamide compound system The client’s mature salon repair serum formula was fixed. European original HA came with a stable buffer system, while domestic raw materials featured a factory pH floating range of 5.0~6.8 without pre-buffering treatment. Compounding with acidic vitamin C disrupted the system’s acid-base balance, and trace metal ions catalyzed flocculation, rendering serum solutions turbid with precipitates and making entire batches of semi-finished products unfit for filling and launch.
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Yellowing oxidation of stock solutions after 1.5~2 months of room-temperature storage Domestic raw materials contained elevated residual trace heavy metals and free proteins. In the client’s original formula without additional antioxidants, metal ions accelerated oxidative decomposition of HA, turning clear liquids pale yellow with excessive oxidized impurities. This failed to meet the internal control standards of Spanish medical aesthetic raw materials and posed skin sensitization risks.
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Upstream Raw Material Root Causes Raw material fermentation adopted conventional animal peptones, with only two-stage filtration for refining, resulting in high residual protein and heavy metals. No powder granulation process was implemented, leading to a wide particle size distribution (PD＞1.42). No pre-adjustment of pH was conducted before delivery, with no buffer base to adapt to compound formulas.
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Client Formula Design Defects Formulas were fully developed based on physicochemical parameters of European HA without reserved space for auxiliary material adjustment. No chelating agents, buffer salts or compound antioxidants were added, resulting in an extremely low formula fault tolerance unable to adapt to impurity and pH characteristics of domestic raw materials.
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Client Production Process Defects All production parameters were copied from standards for European raw materials, with feeding temperature control and stirring speed uncalibrated for the physical properties of domestic HA.
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1. Coordinate manufacturers to switch to plant-source fermentation nitrogen sources and upgrade four-stage ultrafiltration + activated carbon deep impurity removal processes, strictly controlling protein content ＜0.01% and single heavy metal element ＜0.2ppm.
2. Optimize powder granulation processes to narrow the particle size distribution to PD＜1.3 and add small amounts of food-grade trehalose to improve dispersibility and resolve dry powder agglomeration upon contact with water.
3. Pre-adjust buffer bases before delivery to lock the pH of 1% aqueous solution within a narrow range of 5.3~5.5 and reduce acid-base conflicts in subsequent formulas.
1. Optimization of Vitamin C + Niacinamide Repair Serum Formula ① Add a composite chelating agent of disodium EDTA and phytic acid to complex trace heavy metals in raw materials and block ion-induced flocculation triggers; ② Supplement a citric acid-sodium citrate buffer system to lock the final formula pH at 4.3±0.1 within the dual stable range of HA and vitamin C, completely eliminating precipitation and turbidity; ③ Add small amounts of plant-based antioxidants to suppress oxidative yellowing during storage.
2. Fine-Tuning of Medium Molecular Weight Aqua Light Stock Solution Formula Reduce inorganic salt additions in the formula to avoid HA molecular coiling and precipitation caused by sudden ionic strength changes, and synchronously optimize auxiliary material combinations to adapt to the viscosity characteristics of domestic raw materials.
1. Feeding Process Rectification: Abandon direct pouring of dry powder into water. Adopt glycerol pre-dispersion of HA dry powder followed by slow sprinkling into purified water at low temperature. Conduct sealed hydration at 25~30℃ for 12 hours prior to homogenization to fundamentally eliminate agglomeration during operation.
2. Homogenization Parameter Optimization: Lower homogenization temperature from 78℃ to 52℃ and reduce stirring linear speed to minimize mechanical shear damage to macromolecules, stabilizing finished product molecular weight and viscosity.
3. Warehouse Control Optimization: Store raw materials in sealed environments at a constant temperature of 20℃ with humidity ≤30%. Use opened raw materials within 24 hours and seal residual raw materials in vacuum aluminum foil packaging.
1. Coordinate manufacturers to issue bilingual COAs complying with the European Pharmacopoeia (EP), with itemized labeling of molecular weight, endotoxin, protein and heavy metal full data.
2. HiSiaddi compiled a compatibility database for domestic HA, marking compatibility taboos, recommended dosages and production reference parameters for HA of different molecular weights to facilitate raw material selection for the client’s subsequent new product R&D.
1. Lab Trials & Factory Pilot Production: Improved raw material samples passed 3-month accelerated stability testing by third-party laboratories in Spain with no precipitation or yellowing of serums. Smooth feeding without agglomeration was achieved during pilot mass production at the client’s workshop, with molecular weight and viscosity fluctuations controlled within the client’s tolerance range, completely eliminating scrapping issues.
2. Client Benefits: 35 tons of raw materials were shipped in 7 batches from Shanghai to Barcelona, Spain with smooth customs clearance. Three medical aesthetic serums and aqua light stock solutions formulated with domestic HA were launched on schedule across high-end Spanish beauty channels. Comprehensive procurement costs decreased by 27% compared to original European imported raw materials. The client renewed an annual procurement order of 42 tons the following year and added customized demand for cross-linked HA.
3. Upstream Raw Material Manufacturer Benefits: Based on this project, standardized processes for EP-grade customized grades were finalized. Export premiums of 29% were achieved for this product line. Supported by this benchmark Spanish client case, multiple European salon brands in Portugal and Greece were developed.
4. HiSiaddi Service Provider Benefits: A standardized technical service solution for hyaluronic acid covering raw material fine-tuning, formula optimization, mass production process calibration and supporting technical documentation was formed, supporting sustained development of mid-to-high-end medical aesthetic raw material clients across Southern Europe.
Formulas and production processes of mid-to-high-end European and American medical skincare brands are developed around the physical properties of European imported HA. General domestic HA grades exhibit inherent differences from imported raw materials in impurities, pH, heat resistance and shear resistance, easily triggering formula and production failures after terminal production. Raw material manufacturers only excel at optimizing indicators of their own products and lack experience in adapting to overseas terminal formulas and production lines. Supported by cross-border technical resources, HiSiaddi fine-tunes raw materials upstream, optimizes terminal formulas midstream and standardizes mass production processes downstream, resolving full-chain technical pain points in one stop. A three-way win-win outcome was realized: overseas clients cut costs and boosted efficiency, domestic manufacturers upgraded export business, and the service provider increased revenue via value-added services.
If you need more formula optimization consulting services, please contact HiSiaddi customer service.
+86-13120989737 
info@hisiaddi.com 
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